Week 2 
Week 2 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 9/15 | LA Chargers | Kansas City | GEHA Field at Arrowhead Stadium  | Prime | ||
| Su | 9/18 | Miami | Baltimore | M&T Bank Stadium | CBS | ||
| Su | 9/18 | NY Jets | Cleveland | FirstEnergy Stadium | CBS | ||
| Su | 9/18 | Washington | Detroit | Ford Field | FOX | ||
| Su | 9/18 | Indianapolis | Jacksonville | TIAA Bank Field | CBS | ||
| Su | 9/18 | Tampa Bay | New Orleans | Caesars Superdome | FOX | ||
| Su | 9/18 | Carolina | NY Giants | MetLife Stadium | FOX | ||
| Su | 9/18 | New England | Pittsburgh | Acrisure Stadium | CBS | ||
| Su | 9/18 | Seattle | San Fran | Levi's Stadium | FOX | ||
| Su | 9/18 | Atlanta | LA Rams | SoFi Stadium | FOX | ||
| Su | 9/18 | Cincinnati | Dallas | AT&T Stadium | CBS | ||
| Su | 9/18 | Houston | Denver | Empower Field at Mile High | CBS | ||
| Su | 9/18 | Arizona | Las Vegas | Allegiant Stadium | CBS | ||
| Su | 9/18 | Chicago | Green Bay | Lambeau Field | NBC | ||
| Mo | 9/19 | Tennessee | Buffalo | Highmark Stadium | ESPN | ||
| Mo | 9/19 | Minnesota | Philadelphia | Lincoln Financial Field | ABC | ||