Week 3 
Week 3 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 9/22 | Pittsburgh | Cleveland | FirstEnergy Stadium  | Prime | ||
| Su | 9/25 | New Orleans | Carolina | Bank of America Stadium | FOX | ||
| Su | 9/25 | Houston | Chicago | Soldier Field II | CBS | ||
| Su | 9/25 | Kansas City | Indianapolis | Lucas Oil Stadium | CBS | ||
| Su | 9/25 | Buffalo | Miami | Hard Rock Stadium | CBS | ||
| Su | 9/25 | Detroit | Minnesota | U.S. Bank Stadium | FOX | ||
| Su | 9/25 | Baltimore | New England | Gillette Stadium | FOX | ||
| Su | 9/25 | Cincinnati | NY Jets | MetLife Stadium | CBS | ||
| Su | 9/25 | Las Vegas | Tennessee | Nissan Stadium | FOX | ||
| Su | 9/25 | Philadelphia | Washington | FedEx Field | FOX | ||
| Su | 9/25 | Jacksonville | LA Chargers | SoFi Stadium | CBS | ||
| Su | 9/25 | LA Rams | Arizona | State Farm Stadium | FOX | ||
| Su | 9/25 | Atlanta | Seattle | Lumen Field | FOX | ||
| Su | 9/25 | Green Bay | Tampa Bay | Raymond James Stadium | FOX | ||
| Su | 9/25 | San Fran | Denver | Empower Field at Mile High | NBC | ||
| Mo | 9/26 | Dallas | NY Giants | MetLife Stadium | ESPN | ||