Week 5 
Week 5 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 10/6 | Indianapolis | Denver | Empower Field at Mile High  | Prime | ||
| Su | 10/9 | NY Giants | Green Bay | Tottenham Hotspur Stadium | NFL | ||
| Su | 10/9 | Pittsburgh | Buffalo | Highmark Stadium | CBS | ||
| Su | 10/9 | LA Chargers | Cleveland | FirstEnergy Stadium | CBS | ||
| Su | 10/9 | Houston | Jacksonville | TIAA Bank Field | CBS | ||
| Su | 10/9 | Chicago | Minnesota | U.S. Bank Stadium | FOX | ||
| Su | 10/9 | Detroit | New England | Gillette Stadium | FOX | ||
| Su | 10/9 | Seattle | New Orleans | Caesars Superdome | FOX | ||
| Su | 10/9 | Miami | NY Jets | MetLife Stadium | CBS | ||
| Su | 10/9 | Atlanta | Tampa Bay | Raymond James Stadium | FOX | ||
| Su | 10/9 | Tennessee | Washington | FedEx Field | CBS | ||
| Su | 10/9 | San Fran | Carolina | Bank of America Stadium | CBS | ||
| Su | 10/9 | Philadelphia | Arizona | State Farm Stadium | FOX | ||
| Su | 10/9 | Dallas | LA Rams | SoFi Stadium | FOX | ||
| Su | 10/9 | Cincinnati | Baltimore | M&T Bank Stadium | NBC | ||
| Mo | 10/10 | Las Vegas | Kansas City | GEHA Field at Arrowhead Stadium | ESPN | ||