Week 4 
Week 4 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 9/29 | Miami | Cincinnati | Paycor Stadium  | Prime | ||
| Su | 10/2 | Minnesota | New Orleans | Tottenham Hotspur Stadium | NFL | ||
| Su | 10/2 | Cleveland | Atlanta | Mercedes-Benz Stadium | CBS | ||
| Su | 10/2 | Buffalo | Baltimore | M&T Bank Stadium | CBS | ||
| Su | 10/2 | Washington | Dallas | AT&T Stadium | FOX | ||
| Su | 10/2 | Seattle | Detroit | Ford Field | FOX | ||
| Su | 10/2 | LA Chargers | Houston | NRG Stadium | CBS | ||
| Su | 10/2 | Tennessee | Indianapolis | Lucas Oil Stadium | FOX | ||
| Su | 10/2 | Chicago | NY Giants | MetLife Stadium | FOX | ||
| Su | 10/2 | Jacksonville | Philadelphia | Lincoln Financial Field | CBS | ||
| Su | 10/2 | NY Jets | Pittsburgh | Acrisure Stadium | CBS | ||
| Su | 10/2 | Arizona | Carolina | Bank of America Stadium | FOX | ||
| Su | 10/2 | New England | Green Bay | Lambeau Field | CBS | ||
| Su | 10/2 | Denver | Las Vegas | Allegiant Stadium | CBS | ||
| Su | 10/2 | Kansas City | Tampa Bay | Raymond James Stadium | NBC | ||
| Mo | 10/3 | LA Rams | San Fran | Levi's Stadium | ESPN | ||